Molecular

B-Cell Clonality Testing

– IGH Somatic Hypermutation Used to test chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) specimens.
– IGH Gene Rearrangement Assays Identifies IGH gene rearrangements using three master mixes that target the Framework 1-3 regions.
– IGH Gene Clonality Assays Developed by the BIOMED-2 Group, these assays identify IGH gene rearrangements using three master mixes that target the Framework 1-3 regions, and two master mixes that target the DH-JH rearrangements.
– IGK Gene Clonality Assays Developed by the BIOMED-2 Group, these assays identify IGK gene rearrangements using two master mixes that target the Vk 1-7 segments, the Kappa deletion element, and intron segment.
– IGL Gene Clonality Assays Developed by the BIOMED-2 Group, these assays identify gene rearrangements using a single master mix that targets the Vl 1-3 segments.

T-Cell Clonality Testing

– TCRB Gene Clonality Assays Developed by the BIOMED-2 Group, these assays identify gene rearrangements using three master mixes that target the Vb 1-24 and Db 1&2 gene segments.
– TCRD Gene Clonality Assays Developed by the BIOMED-2 Group, these assays identify gene rearrangements using a single master mix that targets the Vd 1-6 and Dd 2&3 gene segments.
– TCRG Gene Rearrangement Assay 2.0 New multiplex PCR assay can detect the vast majority of TCRG gene rearrangements with a single multiplex master mix.
– TCRG Gene Rearrangement Assay Identifies gene rearrangements with two master mixes that target the Vg gene segments.

For more information, please visit the IVS website.